Midline Guidance Defects in Slit Triple Mutants
نویسندگان
چکیده
Neuron Immediate Early Publication Copyright ©2004 by Cell Press Published Online April 15, 2004 DOI: 10.1016/S0896-627304001795 Conserved Roles for Slit and Robo Proteins in Midline Commissural Axon Guidance Hua Long, Christelle Sabatier, Le Ma, Andrew Plump, Wenlin Yuan, David M. Ornitz, Atsushi Tamada, Fujio Murakami, Corey S. Goodman, and Marc Tessier-Lavigne* Howard Hughes Medical Institute Department of Biological Sciences Stanford University Stanford, California 94305 Howard Hughes Medical Institute Department of Anatomy Department of Biochemistry and Biophysics The University of California, San Francisco San Francisco, California 94143 Department of Molecular Biology and Pharmacology Washington University School of Medicine Saint Louis, Missouri 63110 Division of Behaviour and Neurobiology National Institute for Basic Biology Myodaiji-cho, Okazaki 444-8585 Japan Department of Molecular and Cell Biology University of California, Berkeley Berkeley, California 94720 *Correspondence: [email protected]
منابع مشابه
Drosophila neurexin IV interacts with Roundabout and is required for repulsive midline axon guidance.
Slit/Roundabout (Robo) signaling controls midline repulsive axon guidance. However, proteins that interact with Slit/Robo at the cell surface remain largely uncharacterized. Here, we report that the Drosophila transmembrane septate junction-specific protein Neurexin IV (Nrx IV) functions in midline repulsive axon guidance. Nrx IV is expressed in the neurons of the developing ventral nerve cord,...
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